View Full Version : 59 page critique of 12.4.2 ECSCF report on aspartame: Gold: Murray 2.16.3 rmforall

02-22-2003, 12:27 AM
59 page critique of 12.4.2 ECSCF report on aspartame: Gold: Murray
2.16.3 rmforall

Independent Analysis of the "Opinion of the European Commission,
Scientific Committee on Food: Update on the Safety of Aspartame / E951"
[Dec. 4, 2002]

MS Word (Rich Text Format) Version and

HTML Version: 59 pages, 230 references.

Mark D. Gold for years has provided informed, referenced, balanced, and
civil critiques on aspartame toxicity and related issues on the Net
as a layman expert.
A search on http://groups.google.com/ of the Usenet archive on
"aspartame" always brings this up at the top of the list of 77,200
posts, probably because he intelligently and with firm clarity engages
others in a fair debate:
Re: Aspartame Toxicity 10.10.00: Trocho 6.26.98
Aspartame (NutraSweet, Equal, Canderel, Benevia) is reported by
scientific studies and case histories to be toxic: This story seems to
reappear every few ... misc.kids.health - Oct 20, 2000 by Mark Gold -
View Thread (65 articles)

http://www.HolisticMed.com/aspartame 603-225-2100
Aspartame Toxicity Information Center Mark D. Gold
mgold@shelltown.net 12 East Side Drive #2-18 Concord, NH 03301
"Scientific Abuse in Aspartame Research"

The ECSCF report is available at [23 pages in 2 parts, references]:
safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF:
Murray 1.12.3 rmforall

safety of aspartame Part 2/2 12.4.2: EC HCPD-G SCF:
Murray 1.12.3 rmforall

1. The Explanatory Statement and Draft Report by Anne Ferreira, the
Rapporteur, relating to the
Amendments to the Sweeteners Directive 94/35/EC

2. The Opinion of Aspartame by the Scientific Committee on Food given
4th December 2002

3. SCF website
************************************************** *********************

Table of Contents
Introduction *
Aspartame Industry Influence and the Scientific Committee on Food *
Scientific Committee on Food Does Not Read the Research *
Aspartame and Formaldehyde Poisoning *
Aspartame and Migraines / Headaches *
Aspartame and Seizures *
Aspartame and Brain Cancer *
Aspartame and Reproductive Effects *
Aspartame and Behavior, Cognition, Mood *
Aspartame and Other Effects *
Conclusion *
References *

In 2001, the United Kingdom Food Standards Agency requested that the
European Commission Scientific Committee on Food conduct an updated
review of the artificial sweetener, aspartame / E951 (FSA 2001a).
The Scientific Committee on Food was asked to look at more than 500
scientific papers published between 1988 and 2000 and any other new
scientific research not examined previously by the Committee (FSA
On December 10, 2002, the Scientific Committee on Food published its
final report (SCF 2002).

This response will demonstrate that:

1. Members of the European Commission Scientific Committee on Food
have ethical and financial conflicts of interest with the food industry
that should have disqualified them from participation on the Committee.

2. Members of the Scientific Committee on Food did not read
some or most of the research papers they cited.

3. The report ignored independent research related to
aspartame and instead relied heavily on and frequently cited articles in
books and reviews put together by employees or consultants of the
aspartame manufacturers (Monsanto and Ajinomoto).

4. Persons ingesting aspartame are being exposed to significant
amounts of formaldehyde that has been shown by independent research to
accumulate throughout the body.

5. Aspartame manufacturer-sponsored studies are designed in a way
as to avoid the possibility of finding adverse effects, yet the
Committee accepted these studies without any question.
In contrast, nearly all independent research on aspartame in humans and
animals has found that it can cause problems.

6. Human studies and clinical reports published in the medical
literature linking aspartame use to fibromyalgia, seizures, panic
attacks, mania, brain cancer, migraines / headaches, vertigo, symptoms
related to depression, memory loss, hives, irregular heart beats, and
numerous other symptoms were largely ignored by the Committee.

In addition to the analysis of the Scientific Committee on Food report,
there will be numerous sample aspartame poisoning case reports within
the text to give the reader an idea of the clinical effects being
reported. The reports will be taken from
the medical literature and from the Aspartame Toxicity Information
Center listing of cases (ATIC 1997, 1998).

References [230] for this analysis appear at the end of the report.

Persons ingesting aspartame are being exposure
to significant amounts of formaldehyde that has been shown by
independent research to accumulate throughout the body.
Chronic, low-level exposure to formaldehyde (even without accumulation)
has been shown in human research to cause irreversible genetic damage,
headaches, seizures, neurobehavioral problems, gastrointestinal and
cardiovascular problems, fatigue, chest pains, dizziness, etc.
Exposure to a free-form excitotoxic amino acid from aspartame would be
expected to worsen the adverse effects from chronic formaldehyde

Aspartame manufacturer-sponsored studies are designed in a way as to
avoid the possibility of finding adverse effects, yet the Committee
accepted these studies without any question.
In contrast, nearly all independent research on aspartame in animals or
humans has found that aspartame can cause problems.

Human studies and clinical reports published in the medical literature
linking aspartame use to fibromyalgia, seizures, panic attacks, mania,
brain cancer, migraines / headaches, vertigo, symptoms related to
depression, memory loss, hives, irregular heart beats, vision loss, and
numerous of symptoms were largely ignored by the Committee.

It appears that the Committee obtained most of its information from
aspartame industry public relations books that they repeatedly cited
(Stegink 1984, Tschanz 1996), published reviews by manufacturer
employees (Butchko 1994, Butchko 2001), a report from the French Food
Agency (AFSSA 2002) written by some unknown individual(s), and perhaps
the occasional published study, primarily manufacturer-sponsored
A significant amount of independent research was ignored, and when
independent studies were mentioned, they were quickly labeled as flawed.
There is evidence that the Committee did not read some or most of the
research they cited and is only familiar with
aspartame-related research from the aspartame manufacturer's

It appears that there is far too much food industry influence on the
Scientific Committee on Food.
In fact, it would be unlikely that an unbiased
review could be performed on aspartame, stevia or any other
controversial food related subjects
without refilling the Committee positions from scratch.
New Committee members should meet the following criteria:

1. No food industry ties. Disclosure of past and current ties to
the food industry.

2. History of ability to stand up to food industry interests when

3. Expertise in various specialties (e.g., neuroscience,
toxicology, immunology, etc.).

4. Willingness to read all of the relevant research and hear both
independent and food industry testimony.
************************************************** *********************

Rich Murray, MA Room For All rmforall@att.net
1943 Otowi Road, Santa Fe, New Mexico 87505 USA 505-986-9103

aspartame review: methanol, formaldehyde, formic acid toxicity:
Murray 2.21.3 rmforall

for 968 posts in a public searchable archive

http://groups.yahoo.com/group/aspartame/ 615 member group

formaldehyde & formic acid from methanol in aspartame:
Murray: 12.9.2 rmforall

It is certain that high levels of aspartame use, above 2 liters daily
for months and years, must lead to chronic formaldehyde-formic acid
toxicity, since 11% of aspartame (1,120 mg in 2L diet soda, 5.6 12-oz
cans) is 123 mg methanol (wood alcohol), immediately released into the
body after drinking (unlike the large levels of methanol locked up in
molecules inside many fruits), then quickly transformed into
formaldehyde, which in turn becomes formic acid, both of which in
time become carbon dioxide and water-- however, about 30% of the
methanol remains in the body as cumulative durable toxic metabolites of
formaldehyde and formic acid-- 37 mg daily, a gram every month.
If 10% of the methanol is retained as formaldehyde, that would give 12
mg daily formaldehyde accumulation, about 60 times more than the 0.2 mg
from 10% retention of the 2 mg EPA daily limit for formaldehyde in
drinking water.

Bear in mind that the EPA limit for formaldehyde in
drinking water is 1 ppm,
or 2 mg daily for a typical daily consumption of 2 L of water.

RTM: ATSDR: EPA limit 1 ppm formaldehyde in drinking water July 1999
5.30.2 rmforall

This long-term low-level chronic toxic exposure leads to typical
patterns of increasingly severe complex symptoms, starting with
headache, fatigue, joint pain, irritability, memory loss, and
leading to vision and eye problems and even seizures. In many cases
there is addiction. Probably there are immune system disorders, with a
hypersensitivity to these toxins and other chemicals.

Confirming evidence and a general theory are given by Pall (2002):
testable theory of MCS type diseases, vicious cycle of nitric oxide &
peroxynitrite: MSG: formaldehyde-methanol-aspartame:
Martin L. Pall: Murray: 12.9.2 rmforall

Functional Therapeutics in Neurodegenerative Disease Part 1/2:
Perlmutter 7.15.99: Murray 1.10.3 rmforall

formaldehyde toxicity: Thrasher & Kilburn: Shaham: EPA: Gold: Murray:
Wilson: CIIN: 12.12.2 rmforall

24 recent formaldehyde toxicity [Comet assay] reports:
Murray 12.31.2 rmforall

comet assay finds DNA damage from sucralose, cyclamate, saccharin in
mice: Sasaki YF & Tsuda S Aug 2002: Murray 1.1.3 rmforall
[Also borderline evidence, in this pilot study of 39 food additives,
using a test group of 4 mice, for DNA damage from for stomach, colon,
liver, bladder, and lung 3 hr after oral dose of 2000 mg/kg aspartame--
a very high dose.]

genotoxins, Comet assay in mice: Ace-K, stevia fine; aspartame poor;
sucralose, cyclamate, saccharin bad: Y.F. Sasaki Aug 2002:
Murray 1.27.3 rmforall [A detailed look at the data]

aspartame (aspartic acid, phenylalanine) binding to DNA:
Karikas July 1998: Murray 1.5.3 rmforall
Karikas GA, Schulpis KH, Reclos GJ, Kokotos G
Measurement of molecular interaction of aspartame and
its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7.
Dept. of Chemistry, University of Athens, Greece
http://www.chem.uoa.gr gkokotos@atlas.uoa.gr

aspartame & MSG: possible role in autoimmune hepatitis:
Prandota Jan 2003: Murray 1.15.3 rmforall

http://www.dorway.com/tldaddic.html 5-page review
Roberts HJ Aspartame (NutraSweet) addiction.
Townsend Letter 2000 Jan; HJRobertsMD@aol.com
http://www.sunsentpress.com/ sunsentpress@aol.com
Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416
800-814-9800 561-588-7628 561-547-8008 fax

1038-page medical text "Aspartame Disease: An Ignored Epidemic"
published May 30 2001 $ 85.00 postpaid data from 1200 cases
available at http://www.amazon.com
over 600 references from standard medical research

RTM: Smith, Terpening, Schmidt, Gums:
full text: aspartame, MSG, fibromyalgia 1.17.2 rmforall
Jerry D Smith, Chris M Terpening, Siegfried OF Schmidt, and John G Gums
Relief of Fibromyalgia Symptoms Following
Discontinuation of Dietary Excitotoxins.
The Annals of Pharmacotherapy 2001; 35(6): 702–706.
Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA.
BACKGROUND: Fibromyalgia is a common rheumatologic disorder that is
often difficult to treat effectively.
CASE SUMMARY: Four patients diagnosed with fibromyalgia syndrome
for two to 17 years are described.
All had undergone multiple treatment
modalities with limited success. All had complete, or nearly complete,
resolution of their symptoms within months after eliminating monosodium
glutamate (MSG) or MSG plus aspartame from their diet.
All patients were women with multiple comorbidities
prior to elimination of MSG.
All have had recurrence of symptoms whenever MSG is ingested.

Siegfried O. Schmidt, MD Asst. Clinical Prof. siggy@shands.ufl.edu
Community Health and Family Medicine, U. Florida, Gainesville, FL
Shands Hospital
West Oak Clinic Gainesville, FL 32608-3629 352-376-5071

RTM: aspartame in Merck Maxalt-MLT worsens migraine,
AstraZeneca Zomig, Eli Lilly Zyprexa,
J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab,
Pfizer Cool Mint Listerine Pocketpaks 7.16.2 rmforall
Migraine MLT-Down: an unusual presentation of migraine
in patients with aspartame-triggered headaches.
Newman LC, Lipton RB Headache 2001 Oct; 41(9): 899-901.
[Merck 10-mg Maxalt-MLT, for migraine, has 3.75 mg aspartame,
while 12 oz diet soda has 200 mg.]
Headache Institute, St. Lukes-Roosevelt Hospital Center, New York, NY
Department of Neurology newmanache@aol.com
Albert Einstein College of Medicine, Bronx, NY
Innovative Medical Research RLipton@IMRInc.com

RTM: Blumenthall & Vance:
aspartame chewing gum headaches Nov 1997 7.28.2 rmforall
Harvey J. Blumenthal, MD, Dwight A Vance, RPh
Chewing Gum Headaches.
Headache 1997 Nov-Dec; 37(10): 665-6.
Department of Neurology, University of Oklahoma College of Medicine,
Tulsa, USA. neurotulsa@aol.com
Aspartame, a popular dietetic sweetener, may provoke headache in some
susceptible individuals. Herein, we describe three cases of young women
with migraine who reported their headaches could be provoked by chewing
gum sweetened with aspartame. [6-8 mg aspartame per stick chewing gum]

aspartame puts formaldehyde adducts into tissues, Part 1/2
full text, Trocho & Alemany 6.26.98: Murray 12.22.2 rmforall

aspartame puts formaldehyde adducts into tissues, Part 2/2
full text, Trocho & Alemany 6.26.98: Murray 12.22.2 rmforall

Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X,
Fernandez-Lopez JA, Alemany M ["Trok-ho"]
Formaldehyde derived from dietary aspartame binds to tissue
components in vivo. Life Sci 1998 Jun 26; 63(5): 337-49.
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia,
Universitat de Barcelona, Spain.
Maria Alemany, PhD (male) alemany@porthos.bio.ub.es

Murray: Butchko, Tephly, McMartin: Alemany: aspartame formaldehyde
adducts in rats 9.8.2 rmforall
Prof. Alemany vigorously affirms the validity of the Trocho study
against criticism:
Butchko, HH et al [24 authors], Aspartame: review of safety.
Regul. Toxicol. Pharmacol. 2002 April 1; 35 (2 Pt 2): S1-93, review
available for $35, [an industry paid organ]. Butchko:
"When all the research on aspartame, including evaluations in both the
premarketing and postmarketing periods, is examined as a whole, it is
clear that aspartame is safe, and there are no unresolved questions
regarding its safety under conditions of intended use."
[They repeatedly pass on the ageless industry deceit that the methanol
in fruits and vegetables is as as biochemically available as that in
aspartame-- see the 1984 rebuttal by Monte, below.]

RTP ties to industry criticized by CSPI: Murray: 12.9.2 rmforall
************************************************** *********************