Yes, the Sasaki study didn't find genotoxicity from a single heavy dose of
Ace-K or stevia in 4 mice each, using the highly sensitive Comet assay on 8
genotoxins, Comet assay in mice: Ace-K, stevia fine; aspartame poor;
sucralose, cyclamate, saccharin bad: Y.F. Sasaki Aug 2002:
Murray 1.27.3 rmforall [A detailed look at the data]
Aspartame at 24 hours had levels too low to reach significance with any
of the 21 control groups.
However, people who are heavy users of aspartame for years are bound to
accumulate toxic metabolites of the three components of aspartame:
methanol 11%, phenylalanine 50%, aspartic acid 29%, all genotoxic
[Trocho (1998), Karakis (1998)].
Comparing the mean control values to the values for the other 7 sweeteners:
Best is acesulfame K, with no significant or high values.
Good is glycyrrhizin (derived from licorice), two 1.4 ratios for Stomach and
Next is stevia, with one high value [above ratio 1.4],
9.48+-1.99 for Bladder, 2000 mg 3 hr, ratio 1.8 .
Aspartame has high values for 2000 mg 3 hr for Stomach, Colon, Liver,
Sucralose has 3 significant values
and 13 high values, for
Stomach, Colon, Kidney, Bladder, Lung, Brain.
Sodium cyclamate has 4 significant values and 10 high values for
Stomach, Colon, Liver, Kidney, Bladder, Lung, Brain, Bone.
Saccharin has 3 highly significant values for Colon, and 13 high values for
Stomach, Colon, Kidney, Lung, Brain, Bone.
Sodium saccharin has 5 highly significant values for Stomach and Colon,
and 14 high values for
Stomach, Liver, Kidney, Bladder, Lung, Brain, Bone.
We should keep in mind that toxicity in humans involves many vulnerable
groups, years of daily use, often evolution of hypersensitivity, and
complex interactions with a multitude of foods, additives, and other toxins.
Notice that stevia did have one high value, for
bladder, which would become significant if a few dozen mice had been tested.
The Sasaki study can readily be expanded by testing primates and
humans,using many more subjects, tissues, levels of dose, durations of
exposure,special subjects (fetus, infant, youth, mature, old, obese, ill,
stressed, specific genetic weaknesses, simultaneous exposure to other
toxins)-- so clearly it is
an astonishing pilot study, that has received very little attention. Sasaki
has not answered any of my posts, so I can only hope he is expanding his
I use my open group archive as a web site, since anyone can access any
of my 1023 posts.
All three of these reviews, which I put on the archive about every three
months, contain this summary of symptoms, roughly in order of prevalence and
development in time:
aspartame review: methanol, formaldehyde, formic acid toxicity:
Murray 9.5.3 rmforall about 30K
aspartame & formaldehyde toxicity: Murray 9.5.3 rmforall
about 25K, more like an article
brief aspartame review: formaldehyde toxicity: Murray 9.5.3 rmforall
Many scientific studies and case histories report: * headaches
* many body and joint pains (or burning, tingling, tremors, twitching,
spasms, cramps, stiffness, numbness, difficulty swallowing) * fever, fatigue,
swollen glands * "mind fog", "feel unreal", poor memory, confusion, anxiety,
irritability, depression, mania, insomnia, dizziness, slurred speech,
sexual problems, poor vision, hearing (deafness, tinnitus), or taste
* red face, itching, rashes, hair loss, burning eyes or throat, dry eyes or mouth,
mouth sores, burning tongue * obesity, bloating, edema, anorexia,
poor appetite or excessive hunger or thirst * breathing problems,
shortness of breath * nausea, diarrhea or constipation * coldness * sweating
* racing heart, low or high blood pressure, erratic blood sugar levels
* hypothryroidism or hyperthyroidism * seizures * birth defects
* brain cancers * addiction * aggrivates diabetes, autism, allergies, ADHD,
fibromyalgia, chronic fatigue syndrome, multiple chemical sensitivity,
multiple sclerosis, and interstitial cystitis (bladder pain).
Rich Murray, MA Room For All firstname.lastname@example.org
1943 Otowi Road, Santa Fe, New Mexico 87505 USA 505-986-9103
Send blank post to: <br />aspartameNMemail@example.com to join<br />free,open, list with searchable archives for toxicity issues.<br />Richard \"Rich\" T. Murray Room For All 1943 Otowi Road Santa Fe, NM 87505<br />firstname.lastname@example.org 505-501-2298