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    Jun 1999
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    http://groups.yahoo.com/group/aspartameNM/message/965
    59 page critique of 12.4.2 ECSCF report on aspartame: Gold: Murray
    2.16.3 rmforall

    http://www.holisticmed.com/aspartame/scf2002.html
    Independent Analysis of the "Opinion of the European Commission,
    Scientific Committee on Food: Update on the Safety of Aspartame / E951"
    [Dec. 4, 2002]

    MS Word (Rich Text Format) Version and

    http://www.holisticmed.com/aspartame...2-response.htm
    HTML Version: 59 pages, 230 references.

    Mark D. Gold for years has provided informed, referenced, balanced, and
    civil critiques on aspartame toxicity and related issues on the Net
    as a layman expert.
    A search on http://groups.google.com/ of the Usenet archive on
    "aspartame" always brings this up at the top of the list of 77,200
    posts, probably because he intelligently and with firm clarity engages
    others in a fair debate:
    Re: Aspartame Toxicity 10.10.00: Trocho 6.26.98
    Aspartame (NutraSweet, Equal, Canderel, Benevia) is reported by
    scientific studies and case histories to be toxic: This story seems to
    reappear every few ... misc.kids.health - Oct 20, 2000 by Mark Gold -
    View Thread (65 articles)

    http://www.HolisticMed.com/aspartame 603-225-2100
    Aspartame Toxicity Information Center Mark D. Gold
    mgold@shelltown.net 12 East Side Drive #2-18 Concord, NH 03301
    http://www.holisticmed.com/aspartame.../methanol.html
    "Scientific Abuse in Aspartame Research"

    The ECSCF report is available at [23 pages in 2 parts, references]:
    http://groups.yahoo.com/group/aspartameNM/message/957
    safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF:
    Murray 1.12.3 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/958
    safety of aspartame Part 2/2 12.4.2: EC HCPD-G SCF:
    Murray 1.12.3 rmforall

    EP, FSA AND SCF WEBSITES
    1. The Explanatory Statement and Draft Report by Anne Ferreira, the
    Rapporteur, relating to the
    Amendments to the Sweeteners Directive 94/35/EC
    http://www.europarl.eu.int/meetdocs/...vi20030121.htm

    2. The Opinion of Aspartame by the Scientific Committee on Food given
    4th December 2002
    http://www.food.gov.uk/news/newsarchive/aspartamereview

    3. SCF website
    http://europa.eu.int/comm/food/fs/sc/scf/out155_en.pdf
    ************************************************** *********************

    [Extracts]
    Table of Contents
    Introduction *
    Aspartame Industry Influence and the Scientific Committee on Food *
    Scientific Committee on Food Does Not Read the Research *
    Aspartame and Formaldehyde Poisoning *
    Aspartame and Migraines / Headaches *
    Aspartame and Seizures *
    Aspartame and Brain Cancer *
    Aspartame and Reproductive Effects *
    Aspartame and Behavior, Cognition, Mood *
    Aspartame and Other Effects *
    Conclusion *
    References *

    Introduction
    In 2001, the United Kingdom Food Standards Agency requested that the
    European Commission Scientific Committee on Food conduct an updated
    review of the artificial sweetener, aspartame / E951 (FSA 2001a).
    The Scientific Committee on Food was asked to look at more than 500
    scientific papers published between 1988 and 2000 and any other new
    scientific research not examined previously by the Committee (FSA
    2001b).
    On December 10, 2002, the Scientific Committee on Food published its
    final report (SCF 2002).

    This response will demonstrate that:

    1. Members of the European Commission Scientific Committee on Food
    have ethical and financial conflicts of interest with the food industry
    that should have disqualified them from participation on the Committee.

    2. Members of the Scientific Committee on Food did not read
    some or most of the research papers they cited.

    3. The report ignored independent research related to
    aspartame and instead relied heavily on and frequently cited articles in
    books and reviews put together by employees or consultants of the
    aspartame manufacturers (Monsanto and Ajinomoto).

    4. Persons ingesting aspartame are being exposed to significant
    amounts of formaldehyde that has been shown by independent research to
    accumulate throughout the body.

    5. Aspartame manufacturer-sponsored studies are designed in a way
    as to avoid the possibility of finding adverse effects, yet the
    Committee accepted these studies without any question.
    In contrast, nearly all independent research on aspartame in humans and
    animals has found that it can cause problems.

    6. Human studies and clinical reports published in the medical
    literature linking aspartame use to fibromyalgia, seizures, panic
    attacks, mania, brain cancer, migraines / headaches, vertigo, symptoms
    related to depression, memory loss, hives, irregular heart beats, and
    numerous other symptoms were largely ignored by the Committee.

    In addition to the analysis of the Scientific Committee on Food report,
    there will be numerous sample aspartame poisoning case reports within
    the text to give the reader an idea of the clinical effects being
    reported. The reports will be taken from
    the medical literature and from the Aspartame Toxicity Information
    Center listing of cases (ATIC 1997, 1998).

    References [230] for this analysis appear at the end of the report.

    Conclusion:
    Persons ingesting aspartame are being exposure
    to significant amounts of formaldehyde that has been shown by
    independent research to accumulate throughout the body.
    Chronic, low-level exposure to formaldehyde (even without accumulation)
    has been shown in human research to cause irreversible genetic damage,
    headaches, seizures, neurobehavioral problems, gastrointestinal and
    cardiovascular problems, fatigue, chest pains, dizziness, etc.
    Exposure to a free-form excitotoxic amino acid from aspartame would be
    expected to worsen the adverse effects from chronic formaldehyde
    poisoning.

    Aspartame manufacturer-sponsored studies are designed in a way as to
    avoid the possibility of finding adverse effects, yet the Committee
    accepted these studies without any question.
    In contrast, nearly all independent research on aspartame in animals or
    humans has found that aspartame can cause problems.

    Human studies and clinical reports published in the medical literature
    linking aspartame use to fibromyalgia, seizures, panic attacks, mania,
    brain cancer, migraines / headaches, vertigo, symptoms related to
    depression, memory loss, hives, irregular heart beats, vision loss, and
    numerous of symptoms were largely ignored by the Committee.

    It appears that the Committee obtained most of its information from
    aspartame industry public relations books that they repeatedly cited
    (Stegink 1984, Tschanz 1996), published reviews by manufacturer
    employees (Butchko 1994, Butchko 2001), a report from the French Food
    Agency (AFSSA 2002) written by some unknown individual(s), and perhaps
    the occasional published study, primarily manufacturer-sponsored
    studies.
    A significant amount of independent research was ignored, and when
    independent studies were mentioned, they were quickly labeled as flawed.
    There is evidence that the Committee did not read some or most of the
    research they cited and is only familiar with
    aspartame-related research from the aspartame manufacturer's
    perspective.

    It appears that there is far too much food industry influence on the
    Scientific Committee on Food.
    In fact, it would be unlikely that an unbiased
    review could be performed on aspartame, stevia or any other
    controversial food related subjects
    without refilling the Committee positions from scratch.
    New Committee members should meet the following criteria:

    1. No food industry ties. Disclosure of past and current ties to
    the food industry.

    2. History of ability to stand up to food industry interests when
    necessary.

    3. Expertise in various specialties (e.g., neuroscience,
    toxicology, immunology, etc.).

    4. Willingness to read all of the relevant research and hear both
    independent and food industry testimony.
    ************************************************** *********************

    Rich Murray, MA Room For All rmforall@att.net
    1943 Otowi Road, Santa Fe, New Mexico 87505 USA 505-986-9103

    http://groups.yahoo.com/group/aspartameNM/message/959
    aspartame review: methanol, formaldehyde, formic acid toxicity:
    Murray 2.21.3 rmforall

    http://groups.yahoo.com/group/aspartameNM/messages
    for 968 posts in a public searchable archive

    http://groups.yahoo.com/group/aspartame/ 615 member group

    http://groups.yahoo.com/group/aspartameNM/message/910
    formaldehyde & formic acid from methanol in aspartame:
    Murray: 12.9.2 rmforall

    It is certain that high levels of aspartame use, above 2 liters daily
    for months and years, must lead to chronic formaldehyde-formic acid
    toxicity, since 11% of aspartame (1,120 mg in 2L diet soda, 5.6 12-oz
    cans) is 123 mg methanol (wood alcohol), immediately released into the
    body after drinking (unlike the large levels of methanol locked up in
    molecules inside many fruits), then quickly transformed into
    formaldehyde, which in turn becomes formic acid, both of which in
    time become carbon dioxide and water-- however, about 30% of the
    methanol remains in the body as cumulative durable toxic metabolites of
    formaldehyde and formic acid-- 37 mg daily, a gram every month.
    If 10% of the methanol is retained as formaldehyde, that would give 12
    mg daily formaldehyde accumulation, about 60 times more than the 0.2 mg
    from 10% retention of the 2 mg EPA daily limit for formaldehyde in
    drinking water.

    Bear in mind that the EPA limit for formaldehyde in
    drinking water is 1 ppm,
    or 2 mg daily for a typical daily consumption of 2 L of water.

    http://groups.yahoo.com/group/aspartameNM/message/835
    RTM: ATSDR: EPA limit 1 ppm formaldehyde in drinking water July 1999
    5.30.2 rmforall

    This long-term low-level chronic toxic exposure leads to typical
    patterns of increasingly severe complex symptoms, starting with
    headache, fatigue, joint pain, irritability, memory loss, and
    leading to vision and eye problems and even seizures. In many cases
    there is addiction. Probably there are immune system disorders, with a
    hypersensitivity to these toxins and other chemicals.

    Confirming evidence and a general theory are given by Pall (2002):
    http://groups.yahoo.com/group/aspartameNM/message/909
    testable theory of MCS type diseases, vicious cycle of nitric oxide &
    peroxynitrite: MSG: formaldehyde-methanol-aspartame:
    Martin L. Pall: Murray: 12.9.2 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/946
    Functional Therapeutics in Neurodegenerative Disease Part 1/2:
    Perlmutter 7.15.99: Murray 1.10.3 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/915
    formaldehyde toxicity: Thrasher & Kilburn: Shaham: EPA: Gold: Murray:
    Wilson: CIIN: 12.12.2 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/934
    24 recent formaldehyde toxicity [Comet assay] reports:
    Murray 12.31.2 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/935
    comet assay finds DNA damage from sucralose, cyclamate, saccharin in
    mice: Sasaki YF & Tsuda S Aug 2002: Murray 1.1.3 rmforall
    [Also borderline evidence, in this pilot study of 39 food additives,
    using a test group of 4 mice, for DNA damage from for stomach, colon,
    liver, bladder, and lung 3 hr after oral dose of 2000 mg/kg aspartame--
    a very high dose.]

    http://groups.yahoo.com/group/aspartameNM/message/961
    genotoxins, Comet assay in mice: Ace-K, stevia fine; aspartame poor;
    sucralose, cyclamate, saccharin bad: Y.F. Sasaki Aug 2002:
    Murray 1.27.3 rmforall [A detailed look at the data]

    http://groups.yahoo.com/group/aspartameNM/message/939
    aspartame (aspartic acid, phenylalanine) binding to DNA:
    Karikas July 1998: Murray 1.5.3 rmforall
    Karikas GA, Schulpis KH, Reclos GJ, Kokotos G
    Measurement of molecular interaction of aspartame and
    its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7.
    Dept. of Chemistry, University of Athens, Greece
    http://www.chem.uoa.gr gkokotos@atlas.uoa.gr

    http://groups.yahoo.com/group/aspartameNM/message/960
    aspartame & MSG: possible role in autoimmune hepatitis:
    Prandota Jan 2003: Murray 1.15.3 rmforall

    http://www.dorway.com/tldaddic.html 5-page review
    Roberts HJ Aspartame (NutraSweet) addiction.
    Townsend Letter 2000 Jan; HJRobertsMD@aol.com
    http://www.sunsentpress.com/ sunsentpress@aol.com
    Sunshine Sentinel Press P.O.Box 17799 West Palm Beach, FL 33416
    800-814-9800 561-588-7628 561-547-8008 fax

    http://groups.yahoo.com/group/aspartameNM/message/669
    1038-page medical text "Aspartame Disease: An Ignored Epidemic"
    published May 30 2001 $ 85.00 postpaid data from 1200 cases
    available at http://www.amazon.com
    over 600 references from standard medical research

    http://groups.yahoo.com/group/aspartameNM/message/782
    RTM: Smith, Terpening, Schmidt, Gums:
    full text: aspartame, MSG, fibromyalgia 1.17.2 rmforall
    Jerry D Smith, Chris M Terpening, Siegfried OF Schmidt, and John G Gums
    Relief of Fibromyalgia Symptoms Following
    Discontinuation of Dietary Excitotoxins.
    The Annals of Pharmacotherapy 2001; 35(6): 702–706.
    Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA.
    BACKGROUND: Fibromyalgia is a common rheumatologic disorder that is
    often difficult to treat effectively.
    CASE SUMMARY: Four patients diagnosed with fibromyalgia syndrome
    for two to 17 years are described.
    All had undergone multiple treatment
    modalities with limited success. All had complete, or nearly complete,
    resolution of their symptoms within months after eliminating monosodium
    glutamate (MSG) or MSG plus aspartame from their diet.
    All patients were women with multiple comorbidities
    prior to elimination of MSG.
    All have had recurrence of symptoms whenever MSG is ingested.

    Siegfried O. Schmidt, MD Asst. Clinical Prof. siggy@shands.ufl.edu
    Community Health and Family Medicine, U. Florida, Gainesville, FL
    Shands Hospital
    West Oak Clinic Gainesville, FL 32608-3629 352-376-5071

    http://groups.yahoo.com/group/aspartameNM/message/846
    RTM: aspartame in Merck Maxalt-MLT worsens migraine,
    AstraZeneca Zomig, Eli Lilly Zyprexa,
    J&J Merck Pepcid AC (Famotidine 10mg) Chewable Tab,
    Pfizer Cool Mint Listerine Pocketpaks 7.16.2 rmforall
    Migraine MLT-Down: an unusual presentation of migraine
    in patients with aspartame-triggered headaches.
    Newman LC, Lipton RB Headache 2001 Oct; 41(9): 899-901.
    [Merck 10-mg Maxalt-MLT, for migraine, has 3.75 mg aspartame,
    while 12 oz diet soda has 200 mg.]
    Headache Institute, St. Lukes-Roosevelt Hospital Center, New York, NY
    Department of Neurology newmanache@aol.com
    Albert Einstein College of Medicine, Bronx, NY
    Innovative Medical Research RLipton@IMRInc.com

    http://groups.yahoo.com/group/aspartameNM/message/855
    RTM: Blumenthall & Vance:
    aspartame chewing gum headaches Nov 1997 7.28.2 rmforall
    Harvey J. Blumenthal, MD, Dwight A Vance, RPh
    Chewing Gum Headaches.
    Headache 1997 Nov-Dec; 37(10): 665-6.
    Department of Neurology, University of Oklahoma College of Medicine,
    Tulsa, USA. neurotulsa@aol.com
    Aspartame, a popular dietetic sweetener, may provoke headache in some
    susceptible individuals. Herein, we describe three cases of young women
    with migraine who reported their headaches could be provoked by chewing
    gum sweetened with aspartame. [6-8 mg aspartame per stick chewing gum]

    http://groups.yahoo.com/group/aspartameNM/message/925
    aspartame puts formaldehyde adducts into tissues, Part 1/2
    full text, Trocho & Alemany 6.26.98: Murray 12.22.2 rmforall

    http://groups.yahoo.com/group/aspartameNM/message/926
    aspartame puts formaldehyde adducts into tissues, Part 2/2
    full text, Trocho & Alemany 6.26.98: Murray 12.22.2 rmforall

    http://ww.presidiotex.com/barcelona/index.html
    Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X,
    Fernandez-Lopez JA, Alemany M ["Trok-ho"]
    Formaldehyde derived from dietary aspartame binds to tissue
    components in vivo. Life Sci 1998 Jun 26; 63(5): 337-49.
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia,
    Universitat de Barcelona, Spain.
    http://www.presidiotex.com/barcelona/index.html
    Maria Alemany, PhD (male) alemany@porthos.bio.ub.es

    http://groups.yahoo.com/group/aspartameNM/message/864
    Murray: Butchko, Tephly, McMartin: Alemany: aspartame formaldehyde
    adducts in rats 9.8.2 rmforall
    Prof. Alemany vigorously affirms the validity of the Trocho study
    against criticism:
    Butchko, HH et al [24 authors], Aspartame: review of safety.
    Regul. Toxicol. Pharmacol. 2002 April 1; 35 (2 Pt 2): S1-93, review
    available for $35, [an industry paid organ]. Butchko:
    "When all the research on aspartame, including evaluations in both the
    premarketing and postmarketing periods, is examined as a whole, it is
    clear that aspartame is safe, and there are no unresolved questions
    regarding its safety under conditions of intended use."
    [They repeatedly pass on the ageless industry deceit that the methanol
    in fruits and vegetables is as as biochemically available as that in
    aspartame-- see the 1984 rebuttal by Monte, below.]

    http://groups.yahoo.com/group/aspartameNM/message/911
    RTP ties to industry criticized by CSPI: Murray: 12.9.2 rmforall
    ************************************************** *********************
    Send blank post to: <br />aspartameNM-subscribe@onelist.com to join<br />free,open, list with searchable archives for toxicity issues.<br />Richard \"Rich\" T. Murray Room For All 1943 Otowi Road Santa Fe, NM 87505<br />rmforall@comcast.net 505-501-2298

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