Obviously you would never eat poisoned berries, and yes, we do need the medicines, but hopefully most of us don't ingest the latter on a daily basis.
The most common artificial sweeteners all have negative side effects, both on the body and when they are altered and expelled by the body.
For me, I try to stay away from as much artificial stuff as possible. If you look at the rise of cancers in relation to the introduction of artificial ingredients and heavily processed foods into our environment, there's an apparent correlation.