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  1. #1
    Join Date
    Jun 1999
    Santa Fe, NM 87505, USA

    Ramazzini findings implicate the aspartic acid in cancers from aspartame:
    Samuels: Murray 2005.11.29

    November 29, 2005 Hi Jack, Yes, also, the Ramazzini Foundation
    found evidence that the aspartic acid may the cause of cancers in
    "...the renal pelvis and ureter, peripheral nerves and
    proliferative changes of the olfactory epithelium..."
    in rats fed aspartame, and that females were more vulnerable.

    In mutual service, Rich

    Rich Murray, MA Room For All
    505-501-2298 1943 Otowi Road Santa Fe, New Mexico 87505
    group with 148 members, 1,260 posts in a public, searchable
    ************************************************** ********
    aspartame causes cancer in rats at levels approved for humans, Morando
    Soffritti et al, Ramazzini Foundation, Italy & National Toxicology Program
    of National Institute of Environmental Health Sciences 2005.11.17
    Env. Health Pers. 35 pages: Murray

    page 20:

    " Moreover, carcinogenic effects for the renal pelvis and ureter,
    peripheral nerves and proliferative changes of the olfactory epithelium
    were not observed in the long-term bioassays performed
    in the same conditions at the CMCRC
    on methanol, MTBE or formaldehyde.

    To investigate if the other two metabolites of APM are responsible in
    inducing these lesions,
    it is of paramount importance to perform adequate life-span
    carcinogenicity studies on aspartic acid or phenylalanine.

    It is worthy of note that,
    in a long-term carcinogenicity study on monosodium aspartate (MSA)
    administered with drinking water
    to groups of 50 male and 50 female Fischer-344 rats
    (beginning at 6 weeks of age for 100 weeks and then sacrificed),
    a dose-related

    - 20 -

    hyperplasia of the renal pelvis was observed
    in males and in females (Kitahori et al. 1996).

    The same effect was found, by the same group of investigators,
    in another study in which MSA was administered in drinking water
    to groups of male and female Fischer-344 rats
    to evaluate its promoting activity of carcinogenesis
    of the transitional epithelium of the renal pelvis (Kitamura et al. 1996).

    In both studies, clear evidence was provided of a relationship
    between MSA treatment and transitional cell hyperplasia.
    The authors indicated that calcification could have an important role
    in inducing simple and papillary hyperplasia of
    the renal pelvis transitional cell epithelium and,
    consequently, in the induction of transitional cell tumors.

    In our study, performed on 1,800 Sprague-Dawley rats,
    which are less susceptible to the spontaneous development
    of nephropathies than Fischer rats,
    we observed a dose-related, statistically significant increase
    in the incidence of dysplastic hyperplasia and carcinoma
    of the renal pelvis in females, but none in males,
    when compared to the controls.

    The fact that we observed an increased incidence of kidney
    calcification in females and not in males,
    when compared to the controls, gives added weight
    to the hypothesis that aspartic acid
    may cause preneoplastic and neoplastic lesions of the renal pelvis,
    and that calcification may be the mechanism responsible for this effect. "

    Kitahori Y, Kitamura M, Konoshi N, Matsuda H,
    Tao M, Matsui E et al. 1996.
    Carcinogenicity study of monosodium aspartate in Fisher 344 rats:
    100 weeks treatment.
    J Toxicol Pathol 9: 161-168.

    Kitamura M, Konishi N, Kitahori Y, Fukushima Y,
    Yoshioka N, Hiasa Y. 1996.
    Promoting effect of monosodium aspartate, but not glycine,
    on renal pelvis and urinary bladder carcinogenesis in rat
    induced by N-Butyl-N-(4-Hydroxybutyl)nitrosamine.
    Toxicol Pathol 24: 573-579.
    ************************************************** ********

    ----- Original Message -----
    Sent: Monday, November 28, 2005 11:22 PM
    Subject: Re: my mild reactions to MSG and aspartame:
    Jack Samuels: Rich Murray 2005.11...


    Thanks. I would guess that if you took more aspartame
    than you have in the past, the reaction would be the same
    as the one you experience from MSG.
    It is my belief that most of the reported reactions to aspartame
    are from the aspartic acid content.

    ************************************************** ******* Truth in Labeling Campaign [MSG]
    Adrienne Samuels, PhD The toxicity/safety of processed
    free glutamic acid (MSG): a study in suppression of information.
    Accountability in Research 1999; 6: 259-310. 52-page review
    P.O. Box 2532 Darien, Illinois 60561
    Samuels: Strong: Roberts: Gold: flaws in double-blind studies re
    aspartame and MSG toxicity: Murray 2002.08.01 rmforall
    ************************************************** ********

    From: Rich Murray
    Subject: my mild reactions to MSG and aspartame:
    Jack Samuels: Rich Murray 2005.11.28
    Date: Monday, November 28, 2005 11:09 PM

    my mild reactions to MSG and aspartame:
    Jack Samuels: Rich Murray 2005.11.28

    November 28 2005 Hello Jack,

    I was knocked out about 10 or 20 minutes, running the top of my head into
    a pickup truck door edge as I was bicycling to school in the morning --
    woke up slowly in the ambulance -- hearing the siren was the first
    awareness, then slowly my body. Threw up at a cafeteria in a small
    city about noon. In the hospital two weeks,
    and had a spinal tap to enhance contrast for a brain X-ray,
    recovered at home for about 6 weeks.
    For years until about age 14, reading always gave me a headache --
    I loved to read.

    I get a mild dull headache and fatigue from MSG, and found this spring that
    3 packets of Equal, about the same as 6 oz of diet soda, merely caused a
    slight tinnitus and mental activation for an hour, similar to black or green
    tea, while the conversion to formaldehyde, I think, within ten minutes was
    wiping out the rod-shaped bacteria that gave me mild sinusitis
    for about 6 weeks -- I could view them in my greenish, bloody snot
    at 300X with my microscope -- so that by an hour my sinuses
    were clear, only to be fully infected again 12-14 hours later.
    The same process happened with an ounce of blackberry brandy,
    which provides roughly the same amount of methanol, about 100 mg,
    while 3 ounces produced a mild inebriation,
    with no symptoms the next morning.

    Coffee invariably is addictive, increasing my irritability and energy
    swings, and causing my handwriting to be poor.

    In mutual service, Rich

    ----- Original Message -----
    Sent: Monday, November 28, 2005 7:24 PM
    Subject: Re: ANM: only nine negative reports in last 3 years on Usenet
    groups on Sple...


    I found your E-mail to be of great interest. You mentioned that you
    experienced a severe head injury when you were 10 years of age.

    In an informal survey, we have noted that people with severe sensitivity to
    MSG, and I assume, aspartame, have experienced head injuries.
    For example, in my own case, I have lost consciousness
    from such things as a head on auto collision and a severe boat explosion.

    Is it possible that we have a permanent injury to our blood brain barrier?
    I don't know, and for the present, I am unwilling to have an autopsy.

    Jack Samuels
    ************************************************** ********
    Send blank post to: <br /> to join<br />free,open, list with searchable archives for toxicity issues.<br />Richard \"Rich\" T. Murray Room For All 1943 Otowi Road Santa Fe, NM 87505<br /> 505-501-2298

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